Primary malignant lymphoma of the spleen is uncommon neoplasm, approximately 100
substantiated cases having been reported in the literature. We report one case of
primary malignant lymphoma of the spleen in a 45-Fear-old man, who was presented
with pain in the left upper abdomen together with weight loss and hepatosplenomegaly.
Laboratory findings revealed no specific abnormalities. Abdominal computed tomography
revealed a huge splenic mass. A splenectomy was done.
Removed spleen weighed 1,045 gm and 18 ㎝ in maximum cross. Cut sections showed
a large solitary mass replacing almost entire spleen. Multiple irregular areas of necrosis
were present. Light microscopic feature was compatible with primary malignant
lymphoma of histiocytic type(Rappaport), and large non-cleaved(Lukes-Collins). Electron
microscopic findings revealed plump cytoplasm, smooth and regular nuclear margin,
heterochromatin aggregates along the nuclear membrane, and prominent nucleoli. There
was no evidence of lysosome, phagosomes or erythrophagocytosis. These features were
thought to be compatible with B-cell lymphoma.
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